Premier League clubs could lose over 40 stars over the middle of the season to the African Cup of Nations.
The continental tournament is always held midway through the season and sees established stars head away for a number of weeks.
Around 40 players will depart after the games on Boxing Day with some not returning until the second week of February.
The African Cup of Nations officially begins on January 9 and concludes on February 6.
Cameroon kick off the tournament against Burkina Faso which means December 27 – 13 days previous – is the date players will be leaving their clubs.
Here is a list of the players who could be called up by their nations:
Arsenal
Thomas Partey (Ghana)
Mohamed Elneny (Egypt)
Pierre Emerick Aubameyang (Gabon)
Aston Villa
Mahmoud Trezeguet (Egypt)
Bertrand Traore (Burkina Faso)
Marvelous Nakamba (Zimbabwe)
Brentford
Julian Jeanvier (Guinea)
Frank Onyeka (Nigeria)
Tariqe Fosu-Henry (Ghana)
Brighton
Yves Bissouma (Mali)
Burnley
Maxwel Cornet (Ivory Coast)
Chelsea
Edouard Mendy (Senegal)
Hakim Ziyech (Morocco)
Crystal Palace
Cheikhou Kouyate (Senegal)
Jeffrey Schlupp (Ghana)
Jordan Ayew (Ghana)
Wilfried Zaha (Ivory Coast)
Everton
Jean-Philippe Gbamin (Ivory Coast)
Alex Iwobi (Nigeria)
Leeds United
None
Leicester City
Daniel Amartey (Ghana)
Nampalys Mendy (Senegal)
Wilfred Ndidi (Nigeria)
Kelechi Iheanacho (Nigeria)
Liverpool
Mohamed Salah (Egypt)
Naby Keita (Guinea)
Sadio Mane (Senegal)
Manchester City
Riyad Mahrez (Algeria)
Manchester United
Eric Bailly (Ivory Coast)
Amad Diallo (Ivory Coast)
Newcastle United
None
Norwich City
None
Southampton
Moussa Djenepo (Mali)
Mohammed Salisu (Ghana)
Tottenham Hotspur
None
Watford
Peter Etebo (Nigeria)
William Troost-Ekong (Nigeria)
Adam Masina (Morocco)
Ismaila Sarr (Senegal)
Emmanuel Dennis (Nigeria)
West Ham United
None
Wolves
Romain Saiss (Morocco)
Willy Boly (Ivory Coast